Publications

ISCHEMIA Manuscripts

Kataoka A, Scherrer-Crosbie M., Senior R, Gosselin G, Phaneuf D, Guzman G, Perna G, Lara A, Kedev S, Mortara A, El-Hajjar M, Shaw LJ, Reynolds HR, Picard MH. The value of core lab stress echocardiography interpretations: observations from the ISCHEMIA trial. Cardiovasc Ultrasound. 2015;13:47. Link

Kataoka A, Scherrer-Crosbie M, Dajani KA, Garceau P, Hastings JL, Kohn JA, Srbinovska-Kostovska E, Poggio D, Saric M, Senior R, Sokhon K, Shaw L, Reynolds H, Picard MH. Transient ischemic dilatation during stress echocardiography: an additional marker of significant myocardial ischemia. Echocardiography. 2016 Apr 3. doi: 10.1111/echo.13222. Link

Bagai A, Alexander KP, Berger JS, Senior R, Sajeev C, Pracon R, Mavromatis K, Lopez-Sendón JL, Gosselin G, Diaz A, Perna G, Drozdz J, Humen D, Petrauskiene B, Cheema AN, Phaneuf D, Banerjee S, Miller TD, Kedev S, Schuchlenz H, Stone GW, Goodman SG, Mahaffey KW, Jaffe AS, Rosenberg YD, Bangalore S, Newby LK, Maron DJ, Hochman JS, Chaitman BR. The use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis. Am Heart J. 2017 Aug;190:135-139. doi: 10.1016/j.ahj.2017.04.016. Epub 2017 Jun 16. PMID:28760208. Link

ISCHEMIA Trial Research Group, MaronDJ, Hochman JS, O'Brien SM, Reynolds HR, Boden WE, Stone GW, Bangaore S, Spertus JA, Mark DB, Alexander KP, Shaw L, Berger JS, Ferguson TB Jr, William DO, Harrington RA, Rosenberg Y. International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design. Am Heart J. 2018 Apr 21;201:124-135. doi: 10.1016/j.ahj.2018.04.011. PMID:29778671. Link

Hochman JS, Maron DJ. Letter by Hochman and Maron regarding article, "'Faith Healing' and 'Subtraction Anxiety' in unblinded trials of procedures: Lessons from DEFER and FAME-2 for end points in the ISCHEMIA trial." Circ Cardiovasc Qual Outcomes 2018 Apr;11(4):e004742. doi: 10.1161/CIRCOUTCOMES.118.004742. Link

Bangalore S, Maron DJ, Reynolds HR, Stone GW, O'Brien SM, PhD; ALexander KP, Hochman JS. ISCHEMIA: Establishing the primary end point. Circ Cardiovasc Qual Outcomes. 2018 May;11 (5):e004791. doi:10.1161/CIRCOUTCOMES. 118.004791. Noabstract available. PMID: 29752391. Link

Bangalore S, Maron DJ, Fleg JL, O'Brien SM, Herzog CA, Stone GW, Mark DB, Spertus JA, Alexander KP, Sidhu MS, Chertow GM, Boden WE, Hochman JS; ISCHEMIA-CKD Research Group. International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design. Am Heart J 2018;205:42-52. Link

Maron DJ, Harrington RA, Hochman JS. Planning and conducting the ISCHEMIA trial: Setting the record straight. Circulation 2018;138:1384–1386. Link

Hochman JS, Reynolds HR, Bangalore S, O'Brien S, Alexander KP, Senior R, Boden WE, Stone G, Goodman S, Lopes R, Lopez-Sendon J, White H, Maggioni A, Shaw L, Min J, Picard M, Berman D, Chaitman B, Mark D, Spertus J, Cyr D, Bhargava B, Ruzyllo W, Wander G, Chernyavskiy A, Rosenberg Y, Maron DJ. Baseline characteristics of participants in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA). JAMA Cardiology 2019. Link

Spertus, J. Mark, D. “ISCHEMIA Trial Update”. Am Heart J. 2019 Dec;218:8. Link

Newman JD, Alexander KP, Gu X, O'Brien S, Boden WE, Govindan SC, Senior R, Moorthy N, Rezende PC, Demkow M, Lopez-Sendon JL, Bockeria O, Pandit N, Gosselin G, Stone PH, Spertus JA, Stone GW, Fleg JL, Hochman JS, Maron DJ. Baseline predictors of low-density lipoprotein cholesterol and systolic blood pressure goal attainment after 1 year in the ISCHEMIA trial. Circulation Originally published 13 Nov 2019. Link

Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Boden WE, Chaitman BR, Senior R, López-Sendón J, Alexander KP, Lopes RD, Shaw LJ, Berger JS, Newman JD, Sidhu MS, Goodman SG, Ruzyllo W, Gosselin G, Maggioni AP, White HD, Bhargava B, Min JK, Mancini GBJ, Berman DS, Picard MH, Kwong RY, Ali ZA, Mark DB, Spertus JA, Krishnan MN, Elghamaz A, Moorthy N, Hueb WA, Demkow M, Mavromatis K, Bockeria O, Peteiro J, Miller TD, Szwed H, Doerr R, Keltai M, Selvanayagam JB, Steg PG, Held C, Kohsaka S, Mavromichalis S, Kirby R, Jeffries NO, Harrell FE, Rockhold FW, Broderick S, Ferguson Jr. TB, Williams DO, Harrington RA, Stone GW, Rosenberg Y. Initial Invasive or Conservative Strategy for Stable Coronary Disease. The New England Journal of Medicine. April 9 2020 Link

Spertus JA, Jones PG, Maron DJ, O'Brien SM, Reynolds HR, Rosenberg Y, Stone GW, Harrell FE, Boden WE, Weintraub WS, Baloch K, Mavromatis K, Diaz A, Gosselin G, Newman JD, Mavromichalis S, Alexander KP, Cohen DJ, Bangalore S, Hochman, JS, Mark DB. Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. The New England Journal of Medicine. April 9 2020 Link

Bangalore S, Maron DJ, O'Brien SM, Fleg JL, Kretov EI, Briguori C, Kaul U, Reynolds HR, Mazurek T, Sidhu MS, Berger JS, Mathew RO, Bockeria O, Broderick S, Pracon S, Herzog CA, Huang Z, Stone GW, Boden WE, Newman JD, Ali ZA, Mark DB, Spertus JA, Alexander KP, Chaitman BR, Chertow GM, Hockman JS. Management of Coronary Disease in Patients with Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link

Spertus JA, Jones PG, Maron DJ, Mark DB, O'Brien SM, Fleg JL, Reynolds HR, Stone GW, Sidhu MS, Chaitman BR, Chertow GM, Hochman JS, Bangalore S. Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link

Reynolds HR, Shaw LJ, Min JK, Spertus JA, Chaitman BR, Berman DS, Picard MH, Kwong RY, Bairey-Merz CN, Cyr DD, Lopes RD, Lopez-Sendon JL, Held C, Szwed H, Senior R, Gosselin G, Nair RG, Elghamaz A, Bockeria O, Chen J, Chernyavskiy AM, Bhargava B, Newman JD, Hinic SB, Jaroch J, Hoye A, Berger J, Boden WE, O'Brien SM, Maron DJ, Hochman JS. Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia Secondary Analysis of the ISCHEMIA Randomized Clinical Trial. JAMA Cardiology. March 30, 2020 Link

ISCHEMIA Presentations and Posters at National and International Meetings

Outcomes with Intermediate Left Main Disease on Coronary CT Angiography in the ISCHEMIA trial. (Presented by S. Bangalore at SCAI 2020) Link

Coronary Anatomy, Ischemia and Angina: Associations at Baseline in the ISCHEMIA trial. (Presented by H. Reynolds at ACC 2020) Link

Variation in Myocardial Infarction Rates By Type And Definition In the ISCHEMIA Trial. (Presented by B. Chaitman at ACC 2020) Link

Sex Differences in Stress Test and CCTA Findings and Symptoms in the Randomized Ischemia Trial. (Presented by H. Reynolds at ACC 2020) Link

Predictions of Left Main Disease Using Clinical and Stress Test Parameters. (Presented by R. Senior at ACC 2020) Link

Relationships Of Ischemia Severity And Coronary Artery Disease Extent With Clinical Outcomes In The Ischemia Trial. (Presented by D. Maron at ACC 2020) Link

Clinical And Quality Of Life Outcomes With Invasive Versus Conservative Strategy In Patients With Stable Ischemic Heart Disease Across The Spectrum Of Baseline Kidney Function: Insights From The ISCHEMIA And ISCHEMIA-CKD Trials. (Presented by S. Bangalore at ACC 2020) Link

Natural History Of Symptoms And Stress Echo Findings In Patients With Moderate Or Severe Ischemia And No Obstructive CAD (INOCA): The NHLBI-funded CIAO Ancillary Study To The ISCHEMIA Trial. (Presented by H. Reynolds at ACC 2020) Link