Please Find ISCHEMIA's Most Recently Published Manuscripts Below,

Published Online on March 30, 2020

  • Maron DJ, Hochman JS, Reynolds HR, Bangalore S et al. Initial Invasive or Conservative Strategy for Stable Coronary Disease. The New England Journal of Medicine. April 9 2020 Link
  • Spertus JA, Jones PG, Maron DJ, O'Brien SM et al. Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. The New England Journal of Medicine. April 9 2020 Link
  • Bangalore S, Maron DJ, O'Brien SM, Fleg JL et al. Management of Coronary Disease in Patients with Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link
  • Spertus JA, Jones PG, Maron DJ, Mark DB et al. Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease. The New England Journal of Medicine. April 23 2020 Link
  • Reynolds HR, Shaw LJ, Min JK, Spertus JA et al. Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia Secondary Analysis of the ISCHEMIA Randomized Clinical Trial. JAMA Cardiology. March 30, 2020 Link

The ISCHEMIA and ISCHEMIA-CKD Study Results are available! Please click HERE to see the study results!


The ISCHEMIA Baseline Characteristics Paper Published in February 2019

The ISCHEMIA Baseline Characteristics and Risk Profiles Paper was published in the Journal of the American Medical Association on February 27, 2019.  The paper can be found online HERE.

The ISCHEMIA Design Paper Published in July 2018

The ISCHEMIA Design Paper was published in the American Heart Journal July 2018 edition (Vol. 201) on pages 124-135. A PDF copy of the paper can be found HERE.


What is the ISCHEMIA Study? 

  • An NHLBI-funded international comparative effectiveness study to determine the best way to manage stable ischemic heart disease.
  • Patients with moderate or severe ischemia, with or without stress imaging, may be eligible for participation.

If you are a physician and would like more information, please visit the For Physicians section.

If you are a patient and would like to learn more about the ISCHEMIA study, please visit the For Patients section. 

Why is the ISCHEMIA Study Important?

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide and affects 17,600,000 Americans, resulting in about 450,000 deaths in the United States annually. Globally, 7.2 million deaths are caused by IHD each year.

Medical therapy (medication and lifestyle changes) should always be used to treat IHD. Many doctors routinely use an invasive approach in addition to medical therapy to treat IHD. The trial showed that heart procedures added to taking medicines and making lifestyle changes did not reduce the overall rate of heart attack or death compared with medicines and lifestyle changes alone. However, for people with chest pain symptoms, heart procedures improved symptoms better than medicines and lifestyle changes alone. The more chest pain to begin with, the more symptoms improved after getting a stent or bypass surgery. 

Total Number of Participants Randomized to the ISCHEMIA Trial

There are 5,179 participants (pts) randomized worldwide in the ISCHEMIA study. Click here to see the randomizations by country.

Congratulations to Our Top Randomizing Sites!

Site name Region Study Team Total Rands

Government Medical College


PI: Dr. Sajeev & Dr. Nair SC: Anand, Raj, Ravindran, & Vijayan Sunitha

208 pts

Northwick Park Hospital- Royal Brompton Hospital, London


PI: Senior Co-PI: Elghamaz SC: Kinsey, Kavalakkat, Howard, Bucaj, & Encarnado

202 pts

Sri Jayadeva Institute of Cardiovascular Sciences and Research, Banglore-Karnataka India PI: Dr. Manjunath & Dr. Moorthy SC: Nataraj, Kumbar, & Nayak

149 pts

Atlanta V.A. Medical Center


PI: Dr. Mavromatis SC: Lee, Patel, & Doan

139 pts

Heart Instituto do Coracao - University of Sao Paulo


PI: Dr. Hueb SC: Takiuti

127 pts

Coronary and Structural Heart Diseases Department, Institute of Cardiology, Warsaw


PI: Prof. Demkow SC: Chojnacka, Frelek, & Pracon 127 pts
Hospital Universitario La Paz Spain PI: Dr. Lopez-Sendon SC: Valbuena, Castro, La Paz Mediavilla, Albaladejo & Fernandez-Figares  118 pts
Bakulev Scientific Center for Cardiovascular Surgery Russia PI: Dr. Bockeria SC: O. Bockeria, Aripova & Kudzoeva  113 pts

Complejo Hospitalario Universitario de A Coruna


PI: Dr. Peteiro SC: Blanco & Garcia Gonzalez

 112 pts

Guangdong General Hospital

China PI: Dr. Chen SC: Dong, He, Xia, Yang, & Zhong  102 pts